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1

Identification of factor VIII gene mutations in 101 patients with haemophilia A: mutation analysis by inversion screening and multiplex PCR and CSGE and molecular modelling of 10 novel missense substitutions

G. Jayandharan, R. V. Shaji, S. Baidya, S. C. Nair, M. Chandy, A. Srivastava

Journal:

Year:

2005

Language:

english

File:

PDF, 138 KB

english, 2005

2

A new multiplex PCR and conformation-sensitive gel electrophoresis strategy for mutation detection in the platelet glycoprotein αIIb and β3 genes

G. JAYANDHARAN, E. J. R. NELSON, S. BAIDYA, M. CHANDY, A. SRIVASTAVA

Journal:

Journal of Thrombosis and Haemostasis

Year:

2007

Language:

english

File:

PDF, 484 KB

english, 2007

3

Nanoparticle Coated Viral Vectors for Gene Therapy

Selot, Ruchita, Marepally, Srujan, Kumar Vemula, Praveen, R. Jayandharan, Giridhara

Journal:

Current Biotechnology

Year:

2016

Language:

english

File:

PDF, 726 KB

english, 2016

4

Gene and Cell Therapy: Biology and Applications || Pharmaco-Gene Therapy

Jayandharan, Giridhara R.

Year:

2018

Language:

english

File:

PDF, 650 KB

english, 2018

5

Gene and Cell Therapy: Biology and Applications || Viral- and Non-viral-Based Hybrid Vectors for Gene Therapy

Jayandharan, Giridhara R.

Year:

2018

Language:

english

File:

PDF, 1.03 MB

english, 2018

6

Gene and Cell Therapy: Biology and Applications || Aptamer as Therapeutics for Cancer with Focus on Retinoblastoma

Jayandharan, Giridhara R.

Year:

2018

Language:

english

File:

PDF, 1.08 MB

english, 2018

7

Molecular characterization of novel Adeno-associated virus variants infecting human tissues

Purohit, Nishtha, Jain, Apurv, Mathews, Vikram, Jayandharan, Giridhara R.

Journal:

Year:

2019

File:

PDF, 2.55 MB

2019

8

Identification of factor IX gene defects using a multiplex PCR and CSGE strategy—a first report

G. Jayandharan, R. V. Shaji, M. Chandy, A. Srivastava

Journal:

Journal of Thrombosis and Haemostasis

Year:

2003

Language:

english

File:

PDF, 218 KB

english, 2003

9

Informativeness of linkage analysis for genetic diagnosis of haemophilia A in India

G. Jayandharan, R. V. Shaji, B. George, M. Chandy, A. Srivastava

Journal:

Year:

2004

Language:

english

File:

PDF, 118 KB

english, 2004

10

Genetic diagnosis of haemophilia and other inherited bleeding disorders

F. PEYVANDI, G. JAYANDHARAN, M. CHANDY, A. SRIVASTAVA, S. M. NAKAYA, M. J. JOHNSON, A. R. THOMPSON, A. GOODEVE, I. GARAGIOLA, S. LAVORETANO, M. MENEGATTI, R. PALLA, M. SPREAFICO, L. TAGLIABUE, R. ASSE

Journal:

Year:

2006

Language:

english

File:

PDF, 105 KB

english, 2006

11

Mutations in the MCFD2 gene are predominant among patients with hereditary combined FV and FVIII deficiency (F5F8D) in India

G. JAYANDHARAN, M. SPREAFICO, A. VISWABANDYA, M. CHANDY, A. SRIVASTAVA, F. PEYVANDI

Journal:

Year:

2007

Language:

english

File:

PDF, 448 KB

english, 2007

12

Polymorphism in factor VII gene modifies phenotype of severe haemophilia

G. R. JAYANDHARAN, S. C. NAIR, P. M. POONNOOSE, R. THOMAS, J. JOHN, S. K. KESHAV, R. S. CHERIAN, M. DEVADARISHINI, K. M. LAKSHMI, R. V. SHAJI, A. VISWABANDYA, B. GEORGE, V. MATHEWS, M. CHANDY, A. SRIV

Journal:

Year:

2009

Language:

english

File:

PDF, 91 KB

english, 2009

13

Quality issues in laboratory haemostasis

F. E. PRESTON, G. LIPPI, E. J. FAVALORO, G. R. JAYANDHARAN, E. S. EDISON, A. SRIVASTAVA

Journal:

Year:

2010

Language:

english

File:

PDF, 114 KB

english, 2010

14

Novel missense mutations in two patients with factor XI deficiency (Val271Leu and Tyr351Ser) and one patient with combined factor XI and factor IX deficiency (Phe349Val)

G. JAYANDHARAN, R. V. SHAJI, S. C. NAIR, M. CHANDY, A. SRIVASTAVA

Journal:

Journal of Thrombosis and Haemostasis

Year:

2005

Language:

english

File:

PDF, 105 KB

english, 2005

15

Molecular genetics of hereditary prothrombin deficiency in Indian patients: identification of a novel Ala362→Thr (Prothrombin Vellore 1) mutation

G. JAYANDHARAN, A. VISWABANDYA, S. BAIDYA, S. C. NAIR, R. V. SHAJI, M. CHANDY, A. SRIVASTAVA

Journal:

Journal of Thrombosis and Haemostasis

Year:

2005

Language:

english

File:

PDF, 257 KB

english, 2005

16

Molecular basis of Bernard–Soulier syndrome in 27 patients from India

E. SUMITHA, G. R. JAYANDHARAN, S. DAVID, R. R. JACOB, G. SANKARI DEVI, B. BARGAVI, S. SHENBAGAPRIYA, S. C. NAIR, A. ABRAHAM, B. GEORGE, A. VISWABANDYA, V. MATHEWS, M. CHANDY, A. SRIVASTAVA

Journal:

Journal of Thrombosis and Haemostasis

Year:

2011

Language:

english

File:

PDF, 111 KB

english, 2011

17

Strategies for improving the transduction efficiency of single-stranded adeno-associated virus vectors in vitro and in vivo

Jayandharan, G R, Zhong, L, Li, B, Kachniarz, B, Srivastava, A

Journal:

Year:

2008

Language:

english

File:

PDF, 462 KB

english, 2008

18

Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression

Li Zhong, Baozheng Li, Giridhararao Jayandharan, Cathryn S. Mah, Lakshmanan Govindasamy, Mavis Agbandje-McKenna, Roland W. Herzog, Kirsten A. Weigel-Van Aken, Jacqueline A. Hobbs, Sergei Zolotukhin, N

Journal:

Year:

2008

Language:

english

File:

PDF, 875 KB

english, 2008

19

Genetics of haemostasis

A. C. GOODEVE, D. J. PERRY, T. CUMMING, M. HILL, I. JENNINGS, S. KITCHEN, I. WALKER, E. GRAY, G. R. JAYANDHARAN, E. TUDDENHAM

Journal:

Year:

2012

Language:

english

File:

PDF, 773 KB

english, 2012

20

Molecular basis of Wiskott–Aldrich syndrome in patients from India

Sachin David, Giridhara Rao Jayandharan, Aby Abraham, Rintu R Jacob, Govindanattar Sankari Devi, Nikhil Patkar, Ramachandran V Shaji, Sukesh C Nair, Auro Viswabandya, Rayaz Ahmed, Biju George, Vikram

Journal:

European Journal of Haematology

Year:

2012

Language:

english

File:

PDF, 67 KB

english, 2012

21

High-efficiency transduction of human monocyte-derived dendritic cells by capsid-modified recombinant AAV2 vectors

George V. Aslanidi, Angela E. Rivers, Luis Ortiz, Lakshmanan Govindasamy, Chen Ling, Giridhara R. Jayandharan, Sergei Zolotukhin, Mavis Agbandje-McKenna, Arun Srivastava

Journal:

Year:

2012

Language:

english

File:

PDF, 1.57 MB

english, 2012

22

In Vitro Study of ATP7B (Wilson's Disease) Protein Function

SS Kumar, P Yadav, KA Balasubramanian, A Oommen, G Kurian, G Chandy, GR Jayandharan, CE Eapen, S Mazumdar

Journal:

Journal of Clinical and Experimental Hepatology

Year:

2011

Language:

english

File:

PDF, 72 KB

english, 2011

23

Six novel mutations including triple heterozygosity for Phe31Ser, 514delT and 516T→G factor X gene mutations are responsible for congenital factor X deficiency in patients of Nepali and Indian origin

G. JAYANDHARAN, A. VISWABANDYA, S. BAIDYA, S. C. NAIR, R. V. SHAJI, B. GEORGE, M. CHANDY, A. SRIVASTAVA

Journal:

Journal of Thrombosis and Haemostasis

Year:

2005

Language:

english

File:

PDF, 193 KB

english, 2005

24

Adeno-Associated Virus Serotype 6 Capsid Tyrosine-to-Phenylalanine Mutations Improve Gene Transfer to Skeletal Muscle

Qiao, Chunping, Zhang, Wei, Yuan, Zhenhua, Shin, Jin-Hong, Li, Jianbin, Jayandharan, Giridhara R., Zhong, Li, Srivastava, Arun, Xiao, Xiao, Duan, Dongsheng

Journal:

Human Gene Therapy

Year:

2010

Language:

english

File:

PDF, 319 KB

english, 2010

25

Nuclear factor (NF)-κB and its associated pathways are major molecular regulators of blood-induced joint damage in a murine model of hemophilia

Sen, D., Chapla, A., Walter, N., Daniel, V., Srivastava, A., Jayandharan, G. R.

Journal:

Journal of Thrombosis and Haemostasis

Year:

2013

Language:

english

File:

PDF, 541 KB

english, 2013

26

Optimizing the transduction efficiency of capsid-modified AAV6 serotype vectors in primary human hematopoietic stem cells in vitro and in a xenograft mouse model in vivo

Song, Liujiang, Kauss, M. Ariel, Kopin, Etana, Chandra, Manasa, Ul-Hasan, Taihra, Miller, Erin, Jayandharan, Giridhara R., Rivers, Angela E., Aslanidi, George V., Ling, Chen, Li, Baozheng, Ma, Wenqin,

Journal:

Year:

2013

Language:

english

File:

PDF, 2.43 MB

english, 2013

27

Fluorescent PCR-based gene dose analysis for detection of deletion mutations in carriers of haemophilia

Devi, G. Sankari, Arora, N., Rajkumar, S. V., Edison, E. S., Srivastava, A., Jayandharan, G. R.

Journal:

Year:

2013

Language:

english

File:

PDF, 236 KB

english, 2013

28

Efficient lysis of epithelial ovarian cancer cells by MAGE-A3-induced cytotoxic T lymphocytes using rAAV-6 capsid mutant vector

Batchu, Ramesh B., Gruzdyn, Oksana V., Moreno-Bost, Amberly M., Szmania, Susann, Jayandharan, Giridhararao, Srivastava, Arun, Kolli, Bala K., Weaver, Donald W., van Rhee, Frits, Gruber, Scott A.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.23 MB

english, 2014

29

Diffuse Large B Cell Lymphoma in Wiskott-Aldrich Syndrome: A Case Report and Review of Literature

Senapati, Jayastu, Devasia, Anup J., David, Sachin, Manipadam, Marie Therese, Nair, Sheila, Jayandharan, Giridhara R., George, Biju

Journal:

Indian Journal of Hematology and Blood Transfusion

Year:

2014

Language:

english

File:

PDF, 752 KB

english, 2014

30

Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them

Hareendran, Sangeetha, Balakrishnan, Balaji, Sen, Dwaipayan, Kumar, Sanjay, Srivastava, Alok, Jayandharan, Giridhara R.

Journal:

Reviews in Medical Virology

Year:

2013

Language:

english

File:

PDF, 1019 KB

english, 2013

31

Molecular basis of quantitative fibrinogen disorders in 27 patients from India

Sumitha, E., Jayandharan, G. R., Arora, N., Abraham, A., David, S., Devi, G. S., Shenbagapriya, P., Nair, S. C., George, B., Mathews, V., Chandy, M., Viswabandya, A., Srivastava, A.

Journal:

Year:

2013

Language:

english

File:

PDF, 214 KB

english, 2013

32

High-Efficiency Transduction of Fibroblasts and Mesenchymal Stem Cells by Tyrosine-Mutant AAV2 Vectors for Their Potential Use in Cellular Therapy

Li, Mengxin, Jayandharan, Giridhara R., Li, Baozheng, Ling, Chen, Ma, Wenqin, Srivastava, Arun, Zhong, Li

Journal:

Human Gene Therapy

Year:

2010

Language:

english

File:

PDF, 2.01 MB

english, 2010

33

A Simple Method to Increase the Transduction Efficiency of Single-Stranded Adeno-Associated Virus Vectors In Vitro and In Vivo

Ma, Wenqin, Li, Baozheng, Ling, Chen, Jayandharan, Giridhara R., Srivastava, Arun, Byrne, Barry J.

Journal:

Human Gene Therapy

Year:

2011

Language:

english

File:

PDF, 731 KB

english, 2011

34

Human Hepatocyte Growth Factor Receptor Is a Cellular Coreceptor for Adeno-Associated Virus Serotype 3

Ling, Chen, Lu, Yuan, Kalsi, Jasmine K., Jayandharan, Giridhara R., Li, Baozheng, Ma, Wenqin, Cheng, Binbin, Gee, Samantha W.Y., McGoogan, Katherine E., Govindasamy, Lakshmanan, Zhong, Li, Agbandje-Mc

Journal:

Human Gene Therapy

Year:

2010

Language:

english

File:

PDF, 452 KB

english, 2010

35

Enhanced Transgene Expression from Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines In Vitro and in Murine Hepatocytes In Vivo

Ling, Chen, Wang, Yuan, Lu, Yuan, Wang, Lina, Jayandharan, Giridhara R., Aslanidi, George V., Li, Baozheng, Cheng, Binbin, Ma, Wenqin, Lentz, Thomas, Ling, Changquan, Xiao, Xiao, Samulski, R. Jude, Mu

Journal:

Journal of Virology

Year:

2015

Language:

english

File:

PDF, 2.00 MB

english, 2015

36

A novel mutation c.1048A>T at codon 350(Lys>Stop) in PROC gene causing neonatal purpura fulminans

Jain, Rakhi, T, Leenath, Chandran, Jolly, Jayandharan, Giridhara R., Palle, Arpana, Moses, Prabhakar D.

Journal:

Blood Coagulation & Fibrinolysis

Year:

2013

Language:

english

File:

PDF, 537 KB

english, 2013

37

Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming

Rao, Radhika Arasala, Dhele, Narendra, Cheemadan, Sabna, Ketkar, Alhad, Jayandharan, Giridhara R., Palakodeti, Dasaradhi, Rampalli, Shravanti

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.37 MB

english, 2015

38

Calpeptin Increases the Activity of Upstream Stimulatory Factor and Induces High Level Globin Gene Expression in Erythroid Cells

Lin, I-J., Zhou, Z., Crusselle-Davis, V. J., Moghimi, B., Gandhi, K., Anantharaman, A., Pantic, D., Huang, S., Jayandharan, G., Zhong, L., Srivastava, A., Bungert, J.

Journal:

Journal of Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 1.29 MB

english, 2009

39

Cellular unfolded protein response against viruses used in gene therapy

Sen, Dwaipayan, Balakrishnan, Balaji, Jayandharan, Giridhara R.

Journal:

Frontiers in Microbiology

Year:

2014

Language:

english

File:

PDF, 2.03 MB

english, 2014

40

Activation of the NF- B pathway by adeno-associated virus (AAV) vectors and its implications in immune response and gene therapy

Jayandharan, G. R., Aslanidi, G., Martino, A. T., Jahn, S. C., Perrin, G. Q., Herzog, R. W., Srivastava, A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 612 KB

english, 2011

41

High-efficiency Transduction and Correction of Murine Hemophilia B Using AAV2 Vectors Devoid of Multiple Surface-exposed Tyrosines

Markusic, David M, Herzog, Roland W, Aslanidi, George V, Hoffman, Brad E, Li, Baozheng, Li, Mengxin, Jayandharan, Giridhara R., Ling, Chen, Zolotukhin, Irene, Ma, Wenqin, Zolotukhin, Sergei, Srivastav

Journal:

Molecular Therapy

Year:

2010

Language:

english

File:

PDF, 668 KB

english, 2010

42

Role of Molecular Genetics in Hemophilia: From Diagnosis to Therapy

Jayandharan, Giridhara, Srivastava, Arun, Srivastava, Alok

Journal:

Seminars in Thrombosis and Hemostasis

Year:

2012

Language:

english

File:

PDF, 568 KB

english, 2012

43

The Phenotypic Heterogeneity of Severe Hemophilia

Jayandharan, Giridhara, Srivastava, Alok

Journal:

Seminars in Thrombosis and Hemostasis

Year:

2008

Language:

english

File:

PDF, 232 KB

english, 2008

44

Activation of the NF-κB pathway by adeno-associated virus (AAV) vectors and its implications in immune response and gene therapy

Giridhara R. Jayandharan, George Aslanidi, Ashley T. Martino, Stephan C. Jahn, George Q. Perrin, Roland W. Herzog, Arun Srivastava and Kenneth I. Berns

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.41 MB

english, 2011

45

Optimized Adeno-Associated Virus (AAV)–Protein Phosphatase-5 Helper Viruses for Efficient Liver Transduction by Single-Stranded AAV Vectors: Therapeutic Expression of Factor IX at Reduced Vector Doses

Jayandharan, Giridhara R., Zhong, Li, Sack, Brandon K., Rivers, Angela E., Li, Mengxin, Li, Baozheng, Herzog, Roland W., Srivastava, Arun

Journal:

Human Gene Therapy

Year:

2010

Language:

english

File:

PDF, 516 KB

english, 2010

46

Intra-cellular trafficking of AAV5 vectors

Balakrishnan, Balaji, Giridhara R, Jayandharan

Journal:

Human Gene Therapy Methods

Year:

2016

Language:

english

File:

PDF, 391 KB

english, 2016

47

Targeted delivery of AAV-transduced mesenchymal stromal cells to hepatic tissue for ex vivo gene therapy

Gabriel, Nishanth, Samuel, Rekha, Jayandharan, Giridhara R.

Journal:

Journal of Tissue Engineering and Regenerative Medicine

Year:

2015

Language:

english

File:

PDF, 3.53 MB

english, 2015

48

Synergistic inhibition of PARP-1 and NF-κB signaling downregulates immune response against recombinant AAV2 vectors during hepatic gene therapy

Hareendran, Sangeetha, Ramakrishna, Banumathi, Jayandharan, Giridhara R.

Journal:

European Journal of Immunology

Year:

2016

Language:

english

File:

PDF, 1.24 MB

english, 2016

49

Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy

Sen, Dwaipayan, Balakrishnan, Balaji, Gabriel, Nishanth, Agrawal, Prachi, Roshini, Vaani, Samuel, Rekha, Srivastava, Alok, Jayandharan, Giridhara R.

Journal:

Scientific Reports

Year:

2013

Language:

english

File:

PDF, 1.12 MB

english, 2013

50

Molecular basis of hereditary factor VII deficiency in India: five novel mutations including a double missense mutation (Ala191Glu; Trp364Cys) in 11 unrelated patients

Jayandharan, G. R., Viswabandya, A., Nair, S. C., Chandy, M., Srivastava, A.

Journal:

Year:

2007

Language:

english

File:

PDF, 125 KB

english, 2007

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